tuberculosis remains as an important socioeconomical and medical problem throughout the world and especially in iran. early and timely diagnosis of pulmonary and extrapulmonary tuberculosis is vital to initiate prompt treatment. current diagnostic methods are either slow or lack enough sensitivity or specificity. several mycobacterial antigens are involved in the complex interaction with the im...

Tuberculosis remains as an important socioeconomical and medical problem throughout the world and especially in Iran. Early and timely diagnosis of pulmonary and extrapulmonary tuberculosis is vital to initiate prompt treatment. Current diagnostic methods are either slow or lack enough sensitivity or specificity. Several mycobacterial antigens are involved in the complex interaction with t...

BACKGROUND An elevated interferon-gamma (IFN-gamma) level has been reported in the plasma of patients with pulmonary tuberculosis. Serologic diagnosis of tuberculosis using Antigen 60 immunoglobulin G (A60 IgG) is a well-known diagnostic approach. This study evaluated plasma IFN-y compared to A60 IgG in diagnosing Mycobacterium tuberculosis. METHODS This study recruited 65 patients with tuber...

The A60 antigen complex is a Mycobacterium bovis (BCG) highly immunodominant antigen containing both B and T-cell epitopes. Clinical-serological studies show that elevated anti-A60 titres are present during tuberculosis. We wished to analyze in detail antibody responses against A60 components during the course of tuberculosis. A mixed longitudinal study was designed including individuals at the...

The antigen complex of A60 of Mycobacterium bovis BCG was analyzed by different immunological techniques to assess its relevance to tuberculosis and the involvement of its components in the immune reactions elicited in humans by tuberculous infection. A60 is composed of about 30 components, of which 8 were identified by available monoclonal antibodies (lipoarabinomannan, a glycolipid, and prote...

A series of simulations were performed to evaluate the effects of mature size (WMA; 60, 70, 80 and 90 kg), slaughter weight (SW; 55, 60 and 65 kg) and three diets fed to feedlot lambs. Rations included a traditional diet (C2L) or placing weaned lambs on alfalfa for either 30 (A30) or 60 (A60) d before placing them on the C2L diet (A30-C2L and A60-C2L). Two lamb pricing schemes were used in the ...

Identification of acid-fast bacilli (AFB) in sputum or tissue samples is among definite diagnostic methods of tuberculosis. However, this method of diagnosis is restricted by certain limitations. Serologic diagnosis of tuberculosis (TB) has been used for a long time. The aim of this study was to determine the sensitivity and, specificity of Antigen 60 (A60) IgG, IgA, IgM test results in TB diag...

BACKGROUND The identification of acid-fast bacilli (AFB) in sputum or tissue is the definite diagnosis of tuberculosis. However, this method of diagnosis is restricted by certain limitations. The serologic diagnosis of tuberculosis has been used for a long time. The aim of this study was to determine the sensitivity and specificity of Antigen 60 (A60) immunoglobulin G (IgG) in patients with abn...